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SML1581

Moxifloxacin hydrochloride

Name: Moxifloxacin hydrochloride
Brand: SIGMA

98.0 to 102.0% (HPLC)

Synonym(s):

12-8039, Avalox, BAY12-8039, 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₄FN₃O₄· HCl

CAS Number:

186826-86-8

Molecular Weight:

437.89

NACRES:

NA.77

PubChem Substance ID:

329825971

UNSPSC Code:

12352200

MDL number:

MFCD00949117

Beilstein/REAXYS Number:

8377447

Assay:

98-102% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Product Name

Moxifloxacin hydrochloride, 98-102% (HPLC)

Quality Level

100

assay

98-102% (HPLC)

form

powder

storage condition

desiccated

color

light yellow to yellow

solubility

H₂O: slightly soluble

storage temp.

−20°C

SMILES string

Cl.COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(O)=O

InChI

1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1

InChI key

IDIIJJHBXUESQI-DFIJPDEKSA-N

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Bioactive Small Molecules

General description

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial. Moxifloxacin is a 8-methoxy quinolone and differs from other quinolones.

Application

Moxifloxacin hydrochloride has been used to study its antibacterial action against bacteria that have grown to high density.

Biochem/physiol Actions

Moxifloxacin has proved to be effective in treating sinusitis, community-acquired respiratory tract infection, pneumonia and acute exacerbations of chronic bronchitis. It has improved anti-gram positive activity compared to other fluoroquinolone such as ciprofloxacin and ofloxacin. Moxifloxacin is useful in treating skin infections that is of bacterial origin. It is known to have proper penetration into peripheral tissues and inflammatory fluids. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex. Compared to mammalian DNA gyrase, moxifloxacin has 100 times higher affinity for bacterial DNA gyrase. Moxifloxacin is an antibiotic and works against both Gram-positive and Gram-negative bacteria. Moxifloxacin is being investigated for the treatment of multidrug-resistant tuberculosis.

pictograms

GHS07

signalword

Warning

hcodes

H302,H319,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

pcodes

P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000515776

0000148021

0000452406

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Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians.

Tomoko Hasunuma et al.

British journal of clinical pharmacology, 81(6), 1078-1090 (2016-01-17)

To examine whether strict control of clinical trial conditions could reduce apparent differences of pharmacokinetic (PK) parameters among ethnic groups. Open-label, single dose PK studies of moxifloxacin, simvastatin and meloxicam were conducted in healthy male subjects from three East Asian

The fluoroquinolones.

R C Walker et al.

Mayo Clinic proceedings, 66(12), 1249-1259 (1991-12-01)

The fluoroquinolone class of antibiotics promises to become as diverse and as important as beta-lactam agents. The fluoroquinolones inhibit bacterial DNA gyrase and are bactericidal. All fluoroquinolones have potent activity against most gram-negative bacteria; ciprofloxacin is the most active against

Structural identification and characterization of impurities in moxifloxacin.

Kumar Y R, et al.

Journal of Pharmaceutical and Biomedical Analysis, 34(5), 1125-1129 (2004)

An HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization.

Tekkeli SEK

Acta Chromatographica , 10-10 (2016)

Dual drug delivery from hydrophobic and hydrophilic intraocular lenses: in-vitro and in-vivo studies.

Ana Topete et al.

Journal of controlled release : official journal of the Controlled Release Society, 326, 245-255 (2020-07-20)

Posterior capsule opacification (PCO) still remains the most frequent long term complication after cataract surgery, while endophthalmitis is rare but severe and should be prevented at all cost. Intraocular lenses (IOLs) with different designs (eg. edge and body-haptics angle) and

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Global Trade Item Number

SKU	GTIN
SML1581-50MG	04061837107979
SML1581-250MG	04061837107962

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