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Merck
CN

SML1595

Luliconazole

≥98% (HPLC)

Synonym(s):

(αE)-α-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile, NND 502, [R-(E)]-α-[4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile

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About This Item

Empirical Formula (Hill Notation):
C14H9Cl2N3S2
CAS Number:
187164-19-8
Molecular Weight:
354.28
NACRES:
NA.77
PubChem Substance ID:
329825485
UNSPSC Code:
12352200
MDL number:
MFCD00953915

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InChI

1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1

SMILES string

N#C/C(N1C=NC=C1)=C2SC[C@@H](C3=C(Cl)C=C(Cl)C=C3)S/2

InChI key

YTAOBBFIOAEMLL-REQDGWNSSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

General description

Luliconazole also called LLCZ, {(−)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl) acetonitrile} is optically active compound. It is used as a topical medicine for treating dermatophytosis and dermatitis. It is a potential antifungal against Candida and other fungal infections of skin, groin and feet.

Biochem/physiol Actions

Luliconazole is an imidazole antifungal.
Luliconazole is an imidazole antifungal. Its mechanism of action involves inhibition of ergosterol biosynthesis by inhibition of sterol 14α-demethylase.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000514193
0000514195
0000514195
0000514193
0000408520

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Short-term therapy with luliconazole, a novel topical antifungal imidazole, in guinea pig models of tinea corporis and tinea pedis
Koga H, et al.
Antimicrobial Agents and Chemotherapy, AAC-05255 (2012)
A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections
Gupta AK and Daigle D
Infection and Drug Resistance, 9(6), 1-6 (2016)
In vitro antifungal activities of luliconazole, a new topical imidazole
Koga H, et al.
Medical Mycology, 47(6), 640-647 (2009)

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