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SML1606

Oseltamivir phosphate

Name: Oseltamivir phosphate
Brand: SIGMA

≥98% (HPLC), Neuraminidase inhibitor, powder

Synonym(s):

GS4104, (3R,4R,5S)-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₈N₂O₄ ·H₃PO₄

CAS Number:

204255-11-8

Molecular Weight:

410.40

UNSPSC Code:

12352200

PubChem Substance ID:

329825492

NACRES:

NA.77

MDL number:

MFCD08059548

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Oseltamivir phosphate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -26 to -36°, c = 1 in H₂O

color

white to beige

solubility

H₂O: 30 mg/mL, clear

storage temp.

−20°C

SMILES string

OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1

InChI

1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1

InChI key

PGZUMBJQJWIWGJ-ONAKXNSWSA-N

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Related Categories

Bioactive Small Molecules

Phosphates

Biochem/physiol Actions

Oseltamivir phosphate is an influenza viral neuraminidase inhibitor. Oseltamivir phosphate, an antiviral, is used clinically to treat influenza A and influenza B, and to prevent flu after exposure. Oseltamivir phosphate is hydrolyzed in the liver to its active form, oseltamivir carboxylate, which is an inhibitor of influenza viral neuraminidases essential for viral replication. Oseltamivir has a broad spectrum of activity against a range of influenza A and B subtypes with IC₅₀values for neuraminidases measured from less than 1 nM to approximately 30 nM, depending on the virus subtype.

pictograms

GHS07

signalword

Warning

hcodes

H317,H319,H412

pcodes

P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000433526

0000381757

0000248343

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A drug-disease model describing the effect of oseltamivir neuraminidase inhibition on influenza virus progression.

Mohamed A Kamal et al.

Antimicrobial agents and chemotherapy, 59(9), 5388-5395 (2015-06-24)

A population drug-disease model was developed to describe the time course of influenza virus with and without oseltamivir treatment and to investigate opportunities for antiviral combination therapy. Data included viral titers from 208 subjects, across 4 studies, receiving placebo and

Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations.

Brian E Davies

The Journal of antimicrobial chemotherapy, 65 Suppl 2, ii5-ii10 (2010-03-20)

Influenza is a transmissible viral pathogen that continues to cause substantial morbidity and mortality. Oseltamivir is an orally administered antiviral medication that selectively inhibits the influenza neuraminidase enzymes that are essential for viral replication. Treatment of infected children > or

Probing the effect of quercetin 3-glucoside from Dianthus superbus L against influenza virus infection- In vitro and in silico biochemical and toxicological screening.

Shivraj Hariram Nile et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 135, 110985-110985 (2019-11-26)

Investigation of antiviral and cytotoxic effect of quercetin 3-glucoside (Q3G) from Dianthus superbus L over influenza virus infection and replication were studied. Moreover, anti-influenza mechanism was screened by time-dependent antiviral assay, virus-induced symptoms and related gene expressions. The blockade of

Oseltamivir for the treatment of H1N1 influenza during pregnancy.

R H Beigi et al.

Clinical pharmacology and therapeutics, 98(4), 403-405 (2015-06-26)

Pregnancy heightens the risk of adverse outcomes from influenza infections. This is true for both seasonal epidemics as well as occasional pandemics. Seasonal influenza vaccines are the focus of disease prevention and are recommended for all pregnant women in any

Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses.

C Joaquín Cáceres et al.

Emerging microbes & infections, 10(1), 1832-1848 (2021-08-25)

Seasonal influenza A virus (IAV) infections are among the most important global health problems. FDA-approved antiviral therapies against IAV include neuraminidase inhibitors, M2 inhibitors, and polymerase inhibitor baloxavir. Resistance against adamantanes (amantadine and rimantadine) is widespread as virtually all IAV

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Global Trade Item Number

SKU	GTIN
SML1606-100MG	04061832638423

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