SML1616
ICA-069673
≥98% (HPLC)
Synonym(s):
ICA 069673, N-(2-Chloro-5-pyrimidinyl)-3,4-difluoro-benzamide
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About This Item
Empirical Formula (Hill Notation):
C11H6ClF2N3O
CAS Number:
Molecular Weight:
269.63
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
SMILES string
O=C(C1=CC=C(F)C(F)=C1)NC2=CN=C(Cl)N=C2
InChI
1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18)
InChI key
IIBSHMFXVWTQSJ-UHFFFAOYSA-N
Biochem/physiol Actions
ICA-069673 has higher selectivity towards KV7.2/KV7.3 heterodimeric channels than KV7.3/KV7.5 channels. ICA-069673 is considered as a part of gating modifiers.
ICA-069673 is an orally active, potent and selective KV7.2/KV7.3 (KCNQ2/Q3) channel opener that is active in rodent epilepsy models.
ICA-069673 is an orally active, potent and selective KV7.2/KV7.3 (KCNQ2/Q3) channel opener.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Regulatory Information
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The novel KV7. 2/KV7. 3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility.
Provence A, et al.
Journal of Pharmacology and Experimental Therapeutics, 354(3), 290-301 (2015)
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