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Merck
CN

SML1618

Garenoxacin mesylate monohydrate

≥98% (HPLC)

Synonym(s):

1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methane sulfonic acid salt monohydrate, BMS 284756 mesylate, Ganefloxacin mesylate, Garenfloxacin mesylate, T-3811 mesylate

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About This Item

Empirical Formula (Hill Notation):
C23H20F2N2O4 · CH4O3S · H2O
CAS Number:
223652-90-2
Molecular Weight:
540.53
NACRES:
NA.77
PubChem Substance ID:
329825504
UNSPSC Code:
12352200
MDL number:
MFCD12031996

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InChI

1S/C23H20F2N2O4.CH4O3S.H2O/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30;1-5(2,3)4;/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30);1H3,(H,2,3,4);1H2/t11-;;/m1../s1

SMILES string

OC(C1=CN(C2CC2)C3=C(OC(F)F)C(C4=CC(CN[C@@H]5C)=C5C=C4)=CC=C3C1=O)=O.CS(=O)(O)=O.[H]O[H]

InChI key

IGTHEWGRXUAFKF-NVJADKKVSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Broad spectrum fluoroquinolone antibiotic suitable for treatment of gram-positive and gram-negative bacterial infections
Garenoxacin is a broad spectrum fluoroquinolone antibiotic suitable for treatment of gram-positive and gram-negative bacterial infections. Garenoxacin has a low mutant prevention concentration and a narrow mutant selection window. Data shows that garenoxacin has anti-inflammatory properties. It significantly alleviates LPS-induced IL-8 production through the negative regulation of the ERK1/2 pathway both in the human airway epithelial cell line A549 and the monocyte cell line THP-1.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000237368
0000237368
0000141022
0000141021
096M4725V

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