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SML1620

NGI-1

Name: NGI-1
Brand: SIGMA

≥95% (HPLC), Asparagine (N)-linked glycoslysation inhibitor, powder

Synonym(s):

5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide, ML414

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₂N₄O₃S₂

CAS Number:

790702-57-7

Molecular Weight:

394.51

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

powder

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Properties

Product Name

NGI-1, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C

InChI key

QPKGRLIYJGBKJL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation.

NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation. NGI-1 inhibits the oligosaccharyltransferase, preventing the attachment to the protein. NGI-1 has been shown to induce senescence in receptor tyrosine kinase dependent tumors.

Storage Class

11 - Combustible Solids

wgk

WGK 3

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