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Merck
CN

SML1626

TFCA

≥98% (HPLC)

Synonym(s):

3-(3,4-Dimethoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-2-propenamide, N-(4-Trifluoromethylphenyl) 3,4-dimethoxycinnamamide

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About This Item

Empirical Formula (Hill Notation):
C18H16F3NO3
CAS Number:
895700-18-2
Molecular Weight:
351.32
UNSPSC Code:
12352200
PubChem Substance ID:
329825510
NACRES:
NA.77

Key Documents

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SMILES string

O=C(NC1=CC=C(C(F)(F)F)C=C1)/C=C/C2=CC=C(OC)C(OC)=C2

InChI

1S/C18H16F3NO3/c1-24-15-9-3-12(11-16(15)25-2)4-10-17(23)22-14-7-5-13(6-8-14)18(19,20)21/h3-11H,1-2H3,(H,22,23)/b10-4+

InChI key

KFWWXJZNIMFFRO-ONNFQVAWSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

TFCA is a Liver X receptor α (LXRα) antagonist that reduces lipid accumulation and fatty liver in mice. Apparently TFCA binds to the LXR? ligand binding domain and induces interaction with NCoR corepressor.
TFCA is a Liver X receptor α (LXRα) antagonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
066M4605V

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