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SML1628

Sigma-Aldrich

LMT-28

≥98% (HPLC)

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Synonym(s):
(4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone
Empirical Formula (Hill Notation):
C17H29NO4
CAS Number:
1239600-18-0
Molecular Weight:
311.42
PubChem Substance ID:
329825512

Quality Level

100

Assay

≥98% (HPLC)

form

oil

color

colorless to light yellow, oil

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(C)[C@H](N1C([C@@H](C)[C@H](O)C(CCCCC)=C)=O)COC1=O

InChI

1S/C17H29NO4/c1-6-7-8-9-12(4)15(19)13(5)16(20)18-14(11(2)3)10-22-17(18)21/h11,13-15,19H,4,6-10H2,1-3,5H3/t13-,14+,15+/m0/s1

InChI key

UDXWSYOXIRPYFK-RRFJBIMHSA-N

Biochem/physiol Actions

LMT-28 is a derivative of oxazolidinone. It has the ability to repress the activation of signal transducer and activator of transcription 3 (STAT3) stimulated by interleukin 6 (IL-6). Orally administered LMT-28 reduced arthritis and acute pancreatitis stimulated by collagen in mice pathologic models.
LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor β subunit, Glycoprotein 130 (gp130). Its binding to gp130) results in inhibition of IL-6 activation, and downregulation of levels of p-STAT3. LMT-28 was shown to stimulate phosphorylation of STAT3 and JAK2 protein. IL-6 dysregulation is involved in inflammation and cancers. LMT-28 had inhbitory activity against IL-6–dependent TF-1 cell proliferation and also had therapeutic effect against pancreatitis.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.
Hong SS, et al.
Journal of Immunology, 195(1), 45-237 (2015)
Mónica Romera-Hernández et al.
Cell reports, 30(1), 37-45 (2020-01-09)
Tissue repair requires temporal control of progenitor cell proliferation and differentiation to replenish damaged cells. In response to acute insult, group 3 innate lymphoid cells (ILC3s) regulate intestinal stem cell maintenance and subsequent tissue repair. ILC3-derived IL-22 is important for

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