SML1638
VX-745
≥98% (HPLC)
Synonym(s):
5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one
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About This Item
Empirical Formula (Hill Notation):
C19H9Cl2F2N3OS
CAS Number:
Molecular Weight:
436.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
FC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1
InChI
1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChI key
VEPKQEUBKLEPRA-UHFFFAOYSA-N
Gene Information
human ... MAPK14(1432)
Biochem/physiol Actions
VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα.
VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.
Other Notes
VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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