SML1642
DHED
≥98% (HPLC)
Synonym(s):
(17β)-10,17-Dihydroxy-estra-1,4-dien-3-one, 10β,17β-Dihydroxyestra-1,4-dien-3-one, 3,16-Dihydroxyandrost-5-ene-17,19-dione
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Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -20 to -30°, c = 1 in methanol
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=CC(C=C1)=O
InChI
1S/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h6,9-10,13-16,20-21H,2-5,7-8H2,1H3/t13-,14-,15-,16-,17-,18+/m0/s1
InChI key
UIKDFTLKOKNUJP-UGDFAFBOSA-N
Application
DHED has been used to induce an increase of estrogen levels in 3K transgenic mice with Parkinson′s disease (PD)-like motor syndrome.
Biochem/physiol Actions
DHED (10β,17β-dihydroxyestra-1,4-dien-3-one) is an inactive prodrug that selectively produces estrogen solely in the brain. DHED is converted to 17β-estradiol in the brain by an enzyme only expressed in the CNS, but is inert in the rest of the body. DHED was found to provide neuroprotection in a rat stroke model and reversed neurological symptoms of estrogen deprivation such as memory problems in female rats lacking ovaries.
DHED is a substrate for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent dehydrogenase/reductase. Its expression in the brain is correlated to neuroprotection functionality.
DHED is an inactive prodrug that selectively produces estrogen solely in the brain.
hcodes
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Warning
Hazard Classifications
Repr. 2
Storage Class
11 - Combustible Solids
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