SML1654
R-Ketorolac
≥95% (HPLC), GTPases/ Cdc42 /Rac1 inhibitor, powder
Synonym(s):
(+)-Ketorolac, (1R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;, (R)-(+)-ketorolac, (R)-Ketorolac
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About This Item
Empirical Formula (Hill Notation):
C15H13NO3
CAS Number:
Molecular Weight:
255.27
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Product Name
R-Ketorolac, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D +162 to +178°, c = 1 in methanol
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C(O)[C@H]1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1
InChI
1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m1/s1
InChI key
OZWKMVRBQXNZKK-LLVKDONJSA-N
Biochem/physiol Actions
Ketorolac ((rac)-5-benzoyl-1,2-3H-pyrrolo[1,2a] pyrrole1-carboxylic acid) is a non-steroidal anti-inflammatory drug (NSAID). It is used as a racemic mixture that contains a 1:1 ratio of the R(+) and S(−) stereoisomers. It is broadly used off-label as a parenteral analgesic in children. Ketorolac serves as a non-narcotic analgesic. It prevents the synthesis of prostaglandins, peripheral to the central nervous system.
R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion.
R-Ketorolac is potent and selective Rho-family GTPases Cdc42 and Rac1 allosteric inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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