SML1692
AS8351
≥98% (HPLC)
Synonym(s):
2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone, 311 Iron Chelator, AS-8351, NSC-51355
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About This Item
Empirical Formula (Hill Notation):
C17H13N3O2
CAS Number:
Molecular Weight:
291.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
OC1=CC=C(C=CC=C2)C2=C1/C=N/NC(C3=CC=NC=C3)=O
InChI
1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
InChI key
WQSHHAVECQJKLX-YBFXNURJSA-N
Biochem/physiol Actions
AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. AS8351 is thought to inhibit KDM5B by competing with a-ketoglutarate for chelating iron that KDM5B requires as a co-factor.
AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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