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Merck
CN

SML1692

AS8351

≥98% (HPLC)

Synonym(s):

2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone, 311 Iron Chelator, AS-8351, NSC-51355

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About This Item

Empirical Formula (Hill Notation):
C17H13N3O2
CAS Number:
796-42-9
Molecular Weight:
291.30
NACRES:
NA.77
PubChem Substance ID:
329826020
UNSPSC Code:
12352200
MDL number:
MFCD00033110

Key Documents

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InChI

1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+

SMILES string

OC1=CC=C(C=CC=C2)C2=C1/C=N/NC(C3=CC=NC=C3)=O

InChI key

WQSHHAVECQJKLX-YBFXNURJSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. AS8351 is thought to inhibit KDM5B by competing with a-ketoglutarate for chelating iron that KDM5B requires as a co-factor.
AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B).

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000161932
0000132274
0000132275
0000063189

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