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SML1705

Cbz-B3A

≥98% (HPLC)

Synonym(s):

(8S)-3,8-Bis[[(1,1-dimethylethoxy)carbonyl]amino]-9-oxo-2,4,10,17-tetraazaoctadec-3-enedioic acid 1-(1,1-dimethylethyl) 18-(phenylmethyl) ester

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About This Item

Empirical Formula (Hill Notation):
C35H58N6O9
CAS Number:
1884710-81-9
Molecular Weight:
706.87
UNSPSC Code:
12352200
PubChem Substance ID:
329826030
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(OCC1=CC=CC=C1)NCCCCCCNC([C@H](CCCN/C(NC(OC(C)(C)C)=O)=N\C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)=O

InChI

1S/C35H58N6O9/c1-33(2,3)48-30(44)39-26(20-17-23-37-28(40-31(45)49-34(4,5)6)41-32(46)50-35(7,8)9)27(42)36-21-15-10-11-16-22-38-29(43)47-24-25-18-13-12-14-19-25/h12-14,18-19,26H,10-11,15-17,20-24H2,1-9H3,(H,36,42)(H,38,43)(H,39,44)(H2,37,40,41,45,46)/t26-/m

InChI key

JGEWUYSTHGIDHO-SANMLTNESA-N

Biochem/physiol Actions

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that inhibits the phosphorylation of eIF4E binding protein 1 (4EBP1) and blocks 68% of translation. Cbz-B3A binds to ubiquilins 1, 2, and 4, which prevents mTORC1 activation.
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling.

Other Notes

Light and air sensitive.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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