Name: JNJ-47965567
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₃₂N₄O₂S

CAS Number:

1428327-31-4

Molecular Weight:

488.64

MDL number:

MFCD28334214

UNSPSC Code:

12352200

NACRES:

NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NCC1(CCOCC1)N2CCN(C3=CC=CC=C3)CC2)C4=CC=CN=C4SC5=CC=CC=C5

InChI

1S/C28H32N4O2S/c33-26(25-12-7-15-29-27(25)35-24-10-5-2-6-11-24)30-22-28(13-20-34-21-14-28)32-18-16-31(17-19-32)23-8-3-1-4-9-23/h1-12,15H,13-14,16-22H2,(H,30,33)

InChI key

XREFXUCWSYMIOG-UHFFFAOYSA-N

Biochem/physiol Actions

JNJ-47965567 is a potent P2X7 antagonist with high affinity for the rat receptor (pKi = 8.7). It is centrally available after systemic injection with a superior brain:plasma distribution compared to other available P2X7 antagonists. JNJ-47965567 was shown to suppress epileptic seizures in a mouse model of epilepsy. It appears to have a disease modifying effect since spontaneous seizure rates did not increase once treatment with JNJ-477965567 was stopped.

P2X7 antagonist

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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