Skip to Content
Merck
CN

SML1711

TNCA

≥98% (HPLC)

Synonym(s):

(3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, Lycoperodine-1

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C12H12N2O2
CAS Number:
42438-90-4
Molecular Weight:
216.24
NACRES:
NA.77
PubChem Substance ID:
329826033
UNSPSC Code:
12352200
MDL number:
MFCD00272641
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

TNCA, ≥98% (HPLC)

InChI

1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1

SMILES string

O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1

InChI key

FSNCEEGOMTYXKY-JTQLQIEISA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))

color

white to beige

solubility

1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity.
TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000473882
0000473882
0000203462
0000203462
086M4740V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service