Skip to Content
Merck
CN

SML1714

DCAI

≥95% (HPLC)

Synonym(s):

2-(4,6-Dichloro-2-methyl-1h-indol-3-yl)ethanamine, 4,6-Dichloro-2-methyl-3-aminoethylindole

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C11H12Cl2N2
CAS Number:
299165-92-7
Molecular Weight:
243.13
UNSPSC Code:
12352200
PubChem Substance ID:
329826036
NACRES:
NA.77
MDL number:
MFCD02656500
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

DCAI, ≥95% (HPLC)

SMILES string

Clc1c2c([nH]c(c2CCN)C)cc(c1)Cl

InChI

1S/C11H12Cl2N2/c1-6-8(2-3-14)11-9(13)4-7(12)5-10(11)15-6/h4-5,15H,2-3,14H2,1H3

InChI key

JCTJISIFGZHOFY-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

DCAI, an Inactive Ras, is bound to a GDP and activated by SOS (son of sevenless, among others), which converts it to the active GTP form. DCAI is a known binder to Ras, which inhibits SOS nucleotide exchange, inhibiting Ras activation.
DCAI, an inactive Ras, is bound to a GDP and activated by SOS (son of sevenless, among others) which converts it to the active GTP form.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000513883
0000513883
0000204208
0000204208
0000035294

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jon J G Winter et al.
Journal of medicinal chemistry, 58(5), 2265-2274 (2015-02-20)
Constitutively active mutant KRas displays a reduced rate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resulting in the perpetual activation of Ras pathways. We describe a fragment screening campaign using X-ray crystallography that led to the discovery
Till Maurer et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(14), 5299-5304 (2012-03-21)
The Ras gene is frequently mutated in cancer, and mutant Ras drives tumorigenesis. Although Ras is a central oncogene, small molecules that bind to Ras in a well-defined manner and exert inhibitory effects have not been uncovered to date. Through
Thi B Trinh et al.
ACS combinatorial science, 18(1), 75-85 (2015-12-10)
Cyclic peptides have great potential as therapeutic agents and research tools. However, their applications against intracellular targets have been limited, because cyclic peptides are generally impermeable to the cell membrane. It was previously shown that fusion of cyclic peptides with

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service