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Merck
CN

SML1737

Beraprost sodium

≥98% (HPLC)

Synonym(s):

2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran-5-butanoic acid sodium salt, Procyclin, TRK 100

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About This Item

Empirical Formula (Hill Notation):
C24H29O5 · Na
CAS Number:
88475-69-8
Molecular Weight:
420.47
NACRES:
NA.77
UNSPSC Code:
51111800

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InChI

1S/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;

InChI key

YTCZZXIRLARSET-UEIGIMKUSA-M

SMILES string

[H][C@]12[C@](C[C@H](O)[C@H]2/C=C/[C@H](O)C(CC#CC)C)([H])OC3=C1C=CC=C3CCCC([O-])=O.[Na+]

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

General description

Beraprost sodium is an orally active prostacyclin analog.

Biochem/physiol Actions

Beraprost sodium is a chemically stable analog of prostacyclin PGI2.
Beraprost sodium is a chemically stable analog of prostacyclin PGI2. As other prostanoids, beraprost is a potent vasodilator and possesses antithrombotic, antiproliferative and anti-inflammatory properties. Beraprost sodium activates prostaglandin I (IP) receptor, which is coupled with Gs proteins and activates adenylate cyclase. It has been studied for the treatment of pulmonary hypertension.
Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000511101
0000511101
0000391455
0000391455
0000082916

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