SML1749
Narasin Ready Made Solution
1 mg/ml in DMSO
Synonym(s):
(2R)-2-[(2R,3S,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3,5-dimethyloxan-2-yl]butanoic acid, (4S)-4-Methylsalinomycin, A 28086A, Antibiotic A 28086A, Antibiotic C 7819B, C 7819B, Monteban, Narasin A, Narasul
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About This Item
Product Name
Narasin Ready Made Solution, 1 mg/ml in DMSO
SMILES string
O1[C@H]([C@H](C[C@@H]([C@@H]1[C@@H](CC)C(=O)O)C)C)[C@H]([C@H](O)[C@H](C)C(=O)[C@@H]([C@H]2O[C@@]3(O[C@]4(O[C@@](CC4)([C@@H]5O[C@H]([C@@](CC5)(O)CC)C)C)[C@@H](C=C3)O)[C@@H](C[C@@H]2C)C)CC)C
InChI
1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1
InChI key
VHKXXVVRRDYCIK-CWCPJSEDSA-N
biological source
Streptomyces aureofaciens
form
solution
concentration
1 mg/ml in DMSO
shipped in
dry ice
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
In addition, Narasin inhibits Dengue virus (DENV) at the post-entry stage of viral replication during DENV infection. The inhibition of DENV involves a non-cytotoxic mechanism, therefore, Narasin can be possibly considered as therapeutic agent against DENV infection. A dose dependent curve (0.01-5 μM) showed that Narasin has 50% inhibitory concentration at less than 1 μM against all four serotypes of DENV. The IC50 (μM) of Narasin against four different DENV serotypes was 0.05-0.65 μM.
Other Notes
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
Regulatory Information
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