SML1767
Sparstolonin B
≥98% (HPLC)
Synonym(s):
4,10-Dihydroxy-3H-pyrano[3,4,5-kl]xanthen-3-one, Sparstolenin B, SsnB
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About This Item
Empirical Formula (Hill Notation):
C15H8O5
CAS Number:
Molecular Weight:
268.22
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3
InChI
1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H
InChI key
DHSASSJDMAHICE-UHFFFAOYSA-N
Biochem/physiol Actions
Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.
Potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties
Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. Sparstolonin B inhibits LPS induced inflammation in 3T3- L1 adipocytes, and reduces the body weight of rats fed with high fat diet. Sparstolonin B mitigates inflammation in nonalcoholic steatohepatitis (NASH) in mice model.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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