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SML1770

PhiKan083 hydrochloride

≥98% (HPLC)

Synonym(s):

9-Ethyl-N-methyl-9H-Carbazole-3-methanamine hydrochloride, PK-083 hydrochloride, PK083 hydrochloride, PhiKan-083 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H18N2 · HCl
CAS Number:
Molecular Weight:
274.79
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3.[H]Cl

InChI key

IXWVUPURFWFRNE-UHFFFAOYSA-N

Biochem/physiol Actions

Mutant p53 stabilizer
PhiKan083 is a small molecule that binds within a cavity on the surface of Y220C-mutated p53. This mutation, which is not involved in DNA interaction, causes a destabilization of the protein. PhiKan083 binding acts to stabilize the mutant p53 and slow the rate of denaturation.


wgk

WGK 3

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



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