SML1778
SR0987
≥98% (HPLC)
Synonym(s):
2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propanyl)phenyl)benzamide
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About This Item
Empirical Formula (Hill Notation):
C16H10ClF6NO2
CAS Number:
Molecular Weight:
397.70
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
FC(F)(F)C(O)(C(F)(F)F)c1ccc(cc1)NC(=O)c2c(cccc2)Cl
InChI key
IZVBONMVWLTLNT-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency toward T-cell-specific retinoic acid receptor-related orphan receptor ROR?t (EC50 ~800 nM in cell-based reporter assays) by targeting an allosteric pocket within the RORγt ligand-binding domain (LBD). In addition to upregulating RORγt target gene IL17A expression, SR0987 is shown to simultaneously downregulate surface immune checkpoint protein PD-1 expression by a yet unidentified mechanism among ex vivo differentiated murine TH17 cells, as well as PMA/ionophore-stimulated human Jurkat T cells and murine EL4 T lymphocytes.
SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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