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SML1781

PDD00017273

≥98% (HPLC), powder, poly(ADP-ribose) glycohydrolase inhibitor

Synonym(s):

1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C23H26N6O4S2
CAS Number:
1945950-21-9
Molecular Weight:
514.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD30536372
Assay:
≥98% (HPLC)
Form:
powder
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Product Name

PDD00017273, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NC5(CC5)C)c1cc2c([n]([c]([n]([c]2=O)Cc4[s]c(nc4)C)=O)Cc3[n](nc(c3)C)C)cc1

InChI key

IFWUBRBMMNTBRZ-UHFFFAOYSA-N

Biochem/physiol Actions

PDD00017273 is cell permeable in nature. It is used for specific killing of cells defective in certain homologous recombination (HR) proteins such as breast cancer gene 1/2 (BRCA1/2).
PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), which catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs).
PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), which catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs). PARG has been shown to be involved in the repair of single strand DNA breaks. PDD00017273 is selective for PARG, with EC50 = 26 nM, compared to values of 30 μM for PARP1 and ARH3.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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