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SML1784

BTI-A-404

≥98% (HPLC)

Synonym(s):

4-[4-(Dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C22H26N4O2
CAS Number:
537679-57-5
Molecular Weight:
378.47
UNSPSC Code:
51111800
PubChem Substance ID:
329826063
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C1NC(C2=CC=C(N(C)C)C=C2)C(C(NC3=CC(C)=CC(C)=C3)=O)=C(C)N1

InChI key

JQVNMIXFWKEYQJ-UHFFFAOYSA-N

Biochem/physiol Actions

BTI-A-404 is a potent and selective competitive inverse agonist of human GPR43 (FFAR2).
BTI-A-404 is a potent and selective competitive inverse agonist of human GPR43 (GPR43/Free Fatty Acid Receptor 2, FFAR2) that increases the cyclic AMP level and regulates and reduces acetate-induced cytoplasmic Ca2+ level. BTI-A-404 regulates the downstream signaling pathways of GPR43, including ERK, p38 MAPK, and NF-KB. BTI-A-404 stimulates GLP-1 release.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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