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SML1794

Tenofovir disoproxil fumarate

Name: Tenofovir disoproxil fumarate
Brand: SIGMA

≥98% (HPLC), nRTI inhibitor, powder

Synonym(s):

Bis(POC)PMPA fumarate, Bis{[(Isopropoxycarbonyl)oxy]methyl} ({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonate fumarate

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₀N₅O₁₀P · C₄H₄O₄

CAS Number:

202138-50-9

Molecular Weight:

635.51

UNSPSC Code:

12352200

PubChem Substance ID:

329826069

NACRES:

NA.77

MDL number:

MFCD08141829

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Tenofovir disoproxil fumarate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 3 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

OC(/C=C/C(O)=O)=O.NC1=C2C(N(C[C@@H](C)OCP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)C=N2)=NC=N1

InChI

1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1

InChI key

VCMJCVGFSROFHV-WZGZYPNHSA-N

Description

Biochem/physiol Actions

Tenofovir disoproxil fumarate (tenofovir DF) is a nucleotide analogue with activity against retroviruses, such as human immunodeficiency virus (HIV)-1, HIV-2 and hepadnaviruses.

Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. In a T cell line and primary blood lymphocytes, the antiviral activity of tenofovir disoproxil was shown to be more than 100-fold greater than tenofovir because of its rapid intracellular uptake. Tenofovir disoproxil fumarate has been used alone and in various combinations for the prevention and treatment of HIV/AIDS and chronic hepatitis B infections and is on the World Health Organization′s List of Essential Medicines.

Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI); anti-retroviral.

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Pictograms

GHS08,GHS07

Signal Word

Warning

Hazard Codes

H319,H373,H412

Precautionary Statements

P260 - P264 - P273 - P280 - P305 + P351 + P338 - P314

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - STOT RE 2

Target Organs

Bone,Kidney

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)