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SML1807

SB-258719

≥98% (HPLC)

Synonym(s):

N,3-Dimethyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]benzenesulfonamide, SB 258719

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About This Item

Empirical Formula (Hill Notation):
C18H30N2O2S
CAS Number:
195199-95-2
Molecular Weight:
338.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD05662311
Assay:
≥98% (HPLC)
Form:
oil
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

oil

color

off-white to brown

storage temp.

2-8°C

SMILES string

CC1=CC=CC(S(N(C)[C@H](C)CCN2CCC(C)CC2)(=O)=O)=C1

InChI

1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3

InChI key

AGVNHDNTFYHZNL-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

SB-258719 is a selective and potent 5-HT7 antagonist. SB-258719 reverses the hypothermic effect of 5-CT in mice.
Selective and potent 5-HT7 antagonist

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000148786
0000148785
0000148785
0000148786
017M4718V

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Xin Zhao et al.
Scientific reports, 5, 9043-9043 (2015-03-13)
Fisetin, a natural flavonoid, has been shown in our previous studies to exert antidepressant-like effect. As antidepressant drugs are clinically used to treat chronic neuropathic pain, this work aimed to investigate the potential antinociceptive efficacies of fisetin against neuropathic pain
D R Thomas et al.
British journal of pharmacology, 124(6), 1300-1306 (1998-08-28)
1. The functional profile of the long form of the human cloned 5-HT7 receptor (designated h5-HT7(a)) was investigated using a number of 5-HT receptor agonists and antagonists and compared with its binding profile. Receptor function was measured using adenylyl cyclase
Sarwat Fatima et al.
Molecular oncology, 10(2), 195-212 (2015-10-18)
5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling is highly dysregulated in a majority of HCC, this study explored

Global Trade Item Number

SKUGTIN
SML1807-5MG04061832275963
SML1807-25MG04061832275956

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