SML1813
Ani9
≥98% (HPLC), Anoctamin1 (ANO1) inhibitor, powder
Synonym(s):
(4-Chloro-2-methylphenoxy)-acetic acid [(2-methoxyphenyl)methylene]hydrazide, 2-(4-Chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide, 2-(4-Chloro-2-methylphenoxy)-acetic acid 2-[(2-methoxyphenyl)methylene]hydrazide
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About This Item
Empirical Formula (Hill Notation):
C17H17ClN2O3
CAS Number:
Molecular Weight:
332.78
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
Ani9,
InChI key
KDALDZRKOBJXIE-UHFFFAOYSA-N
SMILES string
CC1=C(OCC(NN=CC2=C(OC)C=CC=C2)=O)C=CC(Cl)=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Application
Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.
Biochem/physiol Actions
2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. Ani9 does not affect the intracellular calcium signaling and CFTR chloride channel activity.
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2.
Seo Y, et al.
PLoS ONE, 11(5), e0155771-e0155771 (2016)
Gq activity-and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, et al.
eLife, 7, e33432-e33432 (2018)
Alexander Klimovich et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(30), 17854-17863 (2020-07-11)
Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident
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