SML1821
Imidafenacin hydrochloride
≥95% (HPLC)
Synonym(s):
2-Methyl-α,α-diphenyl-1H-imidazole-1-butanamide hydrochloride, 4-(2-Methyl-1-imidazolyl)-2,2-diphenylbutanamide hydrochloride, 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride, CID 6433090 hydrochloride, HY-B06626433090 hydrochloride, KRP-197 hydrochloride, ONO-8025 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C20H21N3O · HCl
CAS Number:
Molecular Weight:
355.86
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
2-8°C
SMILES string
[n]3(c(ncc3)C)CCC(c2ccccc2)(c1ccccc1)C(=O)N
InChI key
SQKXYSGRELMAAU-UHFFFAOYSA-N
Biochem/physiol Actions
Imidafenacin exhibits anticholinergic properties. It also has potential therapeutic effects on prostatic hyperplasia.
Imidafenacin is a potent antimuscarinic agent that exhibits selectivity toward muscarinic M3 receptors with Kb of 0.317 nM. Imidafenacin is used for treating overactive bladder.
Imidafenacin is a potent antimuscarinic agent that exhibits selectivity toward muscarinic M3 receptors.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Takanobu Yamazaki et al.
European journal of pharmacology, 791, 72-77 (2016-10-30)
Imidafenacin, an antimuscarinic agent for treating overactive bladder, has an antidiuretic effect, but the detailed mechanisms of action remain unclear. The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic
Masayuki Takeda et al.
Urology, 82(4), 887-893 (2013-08-21)
To evaluate the effects of add-on treatment with an anticholinergic (imidafenacin) on persistent overactive bladder (OAB) symptoms despite α-blocker (tamsulosin) treatment in patients with benign prostatic hyperplasia (BPH). Patients with BPH ≥50 years old, with urinary urgency at least once per
Naoki Aizawa et al.
The Journal of urology, 193(4), 1423-1432 (2014-09-16)
Imidafenacin and fesoterodine are used to treat overactive bladder. Imidafenacin, fesoterodine and its active metabolite 5-hydroxymethyl tolterodine are muscarinic receptor antagonists. It is believed that these agents act on afferent nerves in addition to smooth muscle. We investigated the effects
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1821-25MG | 04061832276236 |
| SML1821-5MG | 04061832276243 |