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Merck
CN

SML1821

Imidafenacin hydrochloride

≥95% (HPLC)

Synonym(s):

2-Methyl-α,α-diphenyl-1H-imidazole-1-butanamide hydrochloride, 4-(2-Methyl-1-imidazolyl)-2,2-diphenylbutanamide hydrochloride, 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride, CID 6433090 hydrochloride, HY-B06626433090 hydrochloride, KRP-197 hydrochloride, ONO-8025 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H21N3O · HCl
CAS Number:
893421-54-0
Molecular Weight:
355.86
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09833703

Key Documents

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Product Name

Imidafenacin hydrochloride, ≥95% (HPLC)

SMILES string

[n]3(c(ncc3)C)CCC(c2ccccc2)(c1ccccc1)C(=O)N

InChI key

SQKXYSGRELMAAU-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Imidafenacin exhibits anticholinergic properties. It also has potential therapeutic effects on prostatic hyperplasia.
Imidafenacin is a potent antimuscarinic agent that exhibits selectivity toward muscarinic M3 receptors with Kb of 0.317 nM. Imidafenacin is used for treating overactive bladder.
Imidafenacin is a potent antimuscarinic agent that exhibits selectivity toward muscarinic M3 receptors.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
126M4710V

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Kuanglei Wang et al.
Bioorganic chemistry, 98, 103757-103757 (2020-03-29)
Carbamyl is considered a privileged structure in medicinal chemistry. It has a wide range of biological activities such as antimicrobial, anticancer, anti-epilepsy, for which the best evidence is a number of marketed carbamyl-containing drugs. Carbamyl is formed of primary amine
Masayuki Takeda et al.
Urology, 82(4), 887-893 (2013-08-21)
To evaluate the effects of add-on treatment with an anticholinergic (imidafenacin) on persistent overactive bladder (OAB) symptoms despite α-blocker (tamsulosin) treatment in patients with benign prostatic hyperplasia (BPH). Patients with BPH ≥50 years old, with urinary urgency at least once per
Naoki Aizawa et al.
The Journal of urology, 193(4), 1423-1432 (2014-09-16)
Imidafenacin and fesoterodine are used to treat overactive bladder. Imidafenacin, fesoterodine and its active metabolite 5-hydroxymethyl tolterodine are muscarinic receptor antagonists. It is believed that these agents act on afferent nerves in addition to smooth muscle. We investigated the effects
Takanobu Yamazaki et al.
European journal of pharmacology, 791, 72-77 (2016-10-30)
Imidafenacin, an antimuscarinic agent for treating overactive bladder, has an antidiuretic effect, but the detailed mechanisms of action remain unclear. The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic
Shiori Kuraoka et al.
Journal of pharmacological sciences, 131(3), 184-189 (2016-07-20)
The present study aimed to directly characterize specific binding sites of tritium ([(3)H])-labeled imidafenacin, a new radioligand for labeling muscarinic receptors, in the bladder and other peripheral or central nervous tissues of rats. Muscarinic receptors in rat tissues were measured

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