SML1839
PFM39
≥98% (HPLC)
Synonym(s):
(5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone, 5-(4-Aminobenzylidene)-2-iminothiazolidin-4-one
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About This Item
Empirical Formula (Hill Notation):
C10H9N3OS
CAS Number:
Molecular Weight:
219.26
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=CC=C(/C=C2SC(NC\2=O)=N)C=C1
InChI
1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5-
InChI key
QXOIZYPBCJHYLN-YVMONPNESA-N
Biochem/physiol Actions
PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity.
PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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