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SML1886

VPC-13566

≥98% (HPLC)

Synonym(s):

2-(7-Methyl-1H-indol-3-yl)quinoline

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About This Item

Empirical Formula (Hill Notation):
C18H14N2
CAS Number:
218464-59-6
Molecular Weight:
258.32
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC=CC2=C1NC=C2C3=NC4=CC=CC=C4C=C3

InChI key

FPKBNOVQNMJTEJ-UHFFFAOYSA-N

Biochem/physiol Actions

VPC-13566 is Binding Function 3 (BF3)-specific inhibitor of the androgen receptor.
VPC-13566 is Binding Function 3 (BF3)-specific inhibitor of the androgen receptor. VPC-13566 potently inhibits AR transcriptional activity by displacement of the BAG1L peptide from the BF3 pocket. VPC-13566 inhibits the growth of various prostate cancer cell lines including an enzalutamide-resistant cell line and inhibits the growth of AR-dependent prostate cancer xenograft in mice.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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