SML1891
PK11007
≥98% (HPLC)
Synonym(s):
5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C6H5ClN2O4S
CAS Number:
Molecular Weight:
236.63
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[S](=O)(=O)(C)c1nc(c(cn1)Cl)C(=O)O
InChI
1S/C6H5ClN2O4S/c1-14(12,13)6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
InChI key
WZUPWJVRWIVWEF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding.
PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.
Matthias R Bauer et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(36), E5271-E5280 (2016-08-24)
The tumor suppressor p53 has the most frequently mutated gene in human cancers. Many of p53's oncogenic mutants are just destabilized and rapidly aggregate, and are targets for stabilization by drugs. We found certain 2-sulfonylpyrimidines, including one named PK11007, to
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