SML1894
SYP-5
≥98% (HPLC)
Synonym(s):
(2E)-1-(5-Hydroxy-2-2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-2-propen-1-one, (E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thio-phen-2-yl)prop-2-en-1-one
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About This Item
Empirical Formula (Hill Notation):
C18H16O3S
CAS Number:
Molecular Weight:
312.38
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI key
OMVURDVBYIJCOI-FNORWQNLSA-N
SMILES string
OC1=C(C=CC(C)(C)O2)C2=CC=C1C(/C=C/C3=CC=CS3)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
SYP-5 is potent and selective inhibitor of HIF-1 activity.
SYP-5 is potent and selective inhibitor of HIF-1 activity that decreases HIF-1α and HIF-1β protein levels under hypoxic condition. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Li-Hui Wang et al.
European journal of pharmacology, 791, 560-568 (2016-10-30)
Hypoxia-inducible factor-1 (HIF-1) plays an essential role in carcinogenesis. The overexpression of HIF-1 induced by hypoxia is closely associated with metastasis, poor prognosis and high mortality. In this study, a novel HIF-1 inhibitor SYP-5 was first observed by the luciferase
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