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SML1900

Sobetirome

Name: Sobetirome
Brand: SIGMA

≥98% (HPLC), thyroid hormone receptor (TR) β and TRα agonist, powder

Synonym(s):

2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid, 3,5-Dimethyl-4-(4′-hydroxy-3′-isopropylbenzyl)phenoxyacetic acid, GC 1, GC-1

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₄O₄

CAS Number:

211110-63-3

Molecular Weight:

328.40

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Sobetirome, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O(CC(=O)O)c1cc(c(c(c1)C)Cc2cc(c(cc2)O)C(C)C)C

InChI

1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)

InChI key

QNAZTOHXCZPOSA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.

Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action.

Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action. Sobetirome is devoid of thyrotoxic adverse effects on the heart, bone, and skeletal muscle.

Storage Class

11 - Combustible Solids

wgk

WGK 3

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