SML1930
CORM-401
Synonym(s):
Mn(CO)4{S2CNMe(CH2CO2H)}, Tetracarbonyl[N-(dithiocarboxy-?S,?S′)-N-methylglycine]manganate
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About This Item
Empirical Formula (Hill Notation):
C8H6MnNO6S2
CAS Number:
Molecular Weight:
331.20
UNSPSC Code:
12352200
NACRES:
NA.77
Form:
powder
Storage condition:
protect from light
form
powder
Quality Segment
storage condition
protect from light
color
light yellow to dark yellow
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1
Biochem/physiol Actions
CORM-401 (Mn(CO)4(S2CNMe(CH2CO2H))) is a manganese-containing carbon monoxide-releasing molecule (CORM) that generates at least three molar equivalents of CO. Due to reversible binding of CO, CORM-401 is relatively stable in solution (0.33 mol eq of CO loss after 4 h in PBS; [CORM-401] = 1 mM at time zero), while increased CO release occurs in the presence of a CO receptor or a ligand to prevent the rebinding of CO (3.2 mol eq of CO transferred to iron with a t1/2 of 0.8 min in the presence of 44 μM myoglobin; [CORM-401] = 10 μM at time zero). CO administration by CORM-401 is reported to uncouple mitochondrial respiration and inhibit glycolysis in human endothelial cells (10-100 μM), and relax isolated rat aortic rings (25 μM) pre-contracted with phenylephrine.
Mn-containing carbon monoxide-releasing molecule (CORM) that generates three-times more CO than CORM-A1 and CORM-3.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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