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Merck
CN

SML1932

A-1210477

≥98% (HPLC)

Synonym(s):

7-(1,3-Dimethyl-5-((4-(4-(methylsulfonyl)piperazin-1-yl)phenoxy)methyl)-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid, 7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C46H55N7O7S
CAS Number:
1668553-26-1
Molecular Weight:
850.04
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI key

MRLDHNSBXWSDDL-UHFFFAOYSA-N

SMILES string

O=C(O)C(N1CCN2CCOCC2)=C(C3=C1C(C4=C(N(N=C4C)C)COC5=CC=C(C=C5)N6CCN(CC6)S(=O)(N(C)C)=O)=CC=C3)CCCOC7=C8C=CC=CC8=CC=C7.[H]Cl

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

A BH3 mimetic that targets MCL-1 with high affinity and selectivity. Selectively inhibits cancer survival in a MCL-1-dependent manner.
A-1210477 is a BH3 mimetic that targets MCL-1 with high affinity (Ki = 0.43 nM) and selectivity (Ki >0.66 μM for BCL-2, BCL-XL, BCL-W, and A1), exhibiting little to no activity toward panels of 80 kinases (IC50 >8.5 μM) and 21 GPCRs (IC50 & EC50 >10 μM). A-1210477 selectively inhibits the survival of MCL-1-dependent (IC50 ~4 μM/multiple myeloma H929, 5.3 μM/NSCLC H2110, 7.2 μM/NSCLC H23), but not BCL-2-dependent RS4;11, cultures via apoptosis induction and potentiates BCL-2/BCL-XL inhibitor ABT-263 (Navitoclax) killing in a variety of cancer cell cultures where ABT-263 alone is ineffective. A-1210477 is also shown to cause cellular MCL-1 upregulation, most likely due to blocking MCL-1 interaction with BH3-only proteins such as NOXA and MULE known to mediate MCL-1 ubiquitylation for proteasomal degradation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000223102
0000223102
0000066105
0000019954
0000019955

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