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SML1942

Drotaverine hydrochloride

Name: Drotaverine hydrochloride
Brand: SIGMA

≥95% (HPLC), powder, PDE inhibitor

Synonym(s):

1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, 3′,4′,6,7-Tetraethoxy-1-benzylidene-1,2,3,4-tetrahydroisoquinoline hydrochloride, Drotaverin hydrochloride, Tetraspasmin-Lefa

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₁NO₄ · HCl

CAS Number:

985-12-6

Molecular Weight:

433.97

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD00347721

Assay:

≥95% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Drotaverine hydrochloride, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CCOC1=CC=C(/C=C2C3=C(CCN/2)C=C(OCC)C(OCC)=C3)C=C1OCC.[H]Cl

InChI

1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;

InChI key

JBFLYOLJRKJYNV-MASIZSFYSA-N

Description

Biochem/physiol Actions

It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant.

A PDE4-selective phosphodiesterase inhibitor and an L-type voltage-dependent calcium channel blocker with in vivo antispasmodic efficacy.

Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker that exhibits in vivo antispasmodic efficacy without anticholinergic effects.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c