SML1957
ML RR-S2 CDA sodium salt
≥95% (HPLC)
Synonym(s):
Dithio-(Rp, Rp)-2′,3′-CDA sodium salt, Dithio-(Rp, Rp)-2′,3′-c-diAMP sodium salt, Dithio-(Rp, Rp)-2′,5′-3′,5′-c-diAMP sodium salt, Dithio-(Rp, Rp)-[cyclic[A(2′,5′)pA(3′,5′)p]] sodium salt
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About This Item
Empirical Formula (Hill Notation):
C20H24N10O10P2S2 · xNa+
CAS Number:
Molecular Weight:
690.54 (free acid basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
shipped in
wet ice
storage temp.
−20°C
SMILES string
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP4([S-])=O)[C@@H](COP(O[C@H]5[C@@H](O)[C@H](N(C=N6)C7=C6C(N)=NC=N7)O[C@@H]5CO4)([S-])=O)O3.[R].[R].[Na+]
Biochem/physiol Actions
A mixed linkage (ML) cyclic di-adenosine bisthiophosphate with potent STING-activating activity and in vivo anti-tumor efficacy.
ML-RR-S2 CDA is a potent STING-activating cyclic di-adenosine (CDA or c-diAMP) nucleotide ligand with the 2′-5′, 3′-5′ mixed phosphodiester linkage (ML) in the [Rp,Rp] configuration and doubly substituted thiophosphate (S2) for optimal phosphodiesterase-resistance and thereby enhanced cellular potency. ML-RR-S2 CDA effectively induces IRF3, NF-kB, and STAT6 transcription activities in a STING-dependent manner in both murine (DC2.4 & BMMs) and human (THP1 & PBMCs) cultures (5-100 μM) as well as displays profound anti-tumor efficacy in vivo (100% growth inhibition of established B16.F10, 4T-1 or CT26 tumor with 3X 50 μg/mouse/96 hr intratumoral injections) with lasting immune-mediated tumor rejection.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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