SML1962
IWP-O1
≥98% (HPLC)
Synonym(s):
IWP-O1, 5-Phenyl-N-(5-phenylpyridin-2-yl)-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-acetamide, IWP-01
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About This Item
Empirical Formula (Hill Notation):
C26H20N6O
CAS Number:
Molecular Weight:
432.48
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
GYYDQHBKIHQHEB-UHFFFAOYSA-N
SMILES string
[n]3(nnc(c3c5ccccc5)c4ccncc4)CC(=O)Nc1ncc(cc1)c2ccccc2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
IWP-O1 is an inhibitor of Porcupine (Porcn), an acyl (palmitoyl) transferase essential for secretion of Wnt proteins and involved in both embryonic development and tumor progression. IWP-O1 has good metabolic stability and is extremely potent, exhibiting an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling.
Porcn Inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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