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SML1991

PS432

≥98% (HPLC)

Synonym(s):

2-[5-(4-chlorophenyl)-2-furanyl]-2,5-dihydro-4-hydroxy-1-(6-methyl-2-benzothiazolyl)-5-oxo-1H-pyrrole-3-carboxylic acid ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C25H19ClN2O5S
CAS Number:
2083630-26-4
Molecular Weight:
494.95
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
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assay

≥98% (HPLC)

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

ambient

storage temp.

2-8°C

SMILES string

O=C1C(O)=C(C(OCC)=O)C(C2=CC=C(C3=CC=C(Cl)C=C3)O2)N1C4=NC(C=CC(C)=C5)=C5S4

Biochem/physiol Actions

Allosteric inhibitor of atypical PKC isoforms
PS432 is an allosteric inhibitor of Protein Kinase C (PKC) that targets regulatory site (PIF-pocket) present in the kinase domain. PS432 potently inhibits non-small cell lung cancer cells proliferation and tumor growth without side effects in a mouse xenograft model.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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