SML1991
PS432
≥98% (HPLC)
Synonym(s):
2-[5-(4-chlorophenyl)-2-furanyl]-2,5-dihydro-4-hydroxy-1-(6-methyl-2-benzothiazolyl)-5-oxo-1H-pyrrole-3-carboxylic acid ethyl ester
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About This Item
Empirical Formula (Hill Notation):
C25H19ClN2O5S
CAS Number:
Molecular Weight:
494.95
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
assay
≥98% (HPLC)
color
white to beige
solubility
DMSO: 2 mg/mL, clear
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C1C(O)=C(C(OCC)=O)C(C2=CC=C(C3=CC=C(Cl)C=C3)O2)N1C4=NC(C=CC(C)=C5)=C5S4
Biochem/physiol Actions
Allosteric inhibitor of atypical PKC isoforms
PS432 is an allosteric inhibitor of Protein Kinase C (PKC) that targets regulatory site (PIF-pocket) present in the kinase domain. PS432 potently inhibits non-small cell lung cancer cells proliferation and tumor growth without side effects in a mouse xenograft model.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jose M Arencibia et al.
ACS chemical biology, 12(2), 564-573 (2017-01-04)
There is a current and pressing need for improved cancer therapies. The use of small molecule kinase inhibitors and their application in combinatorial regimens represent an approach to personalized targeted cancer therapy. A number of AGC kinases, including atypical Protein
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1991-25MG | 04061835302765 |
| SML1991-5MG | 04061835302772 |