SML1996
S3226
≥98% (HPLC), sodium-hydrogen exchanger 3 inhibitor, powder
Synonym(s):
3,3′-(4-Methyl-1,2-phenylene)bis[N-(aminoiminomethyl)-2-methyl-2-propenamide] dihydrochloride, S 3226, S-3226
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About This Item
Empirical Formula (Hill Notation):
C17H22N6O2 · 2HCl
CAS Number:
Molecular Weight:
415.32
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Product Name
S3226, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(N=C(N)N)C(C)=CC1=CC(C)=CC=C1C=C(C)C(NC(N)=N)=O.[H]Cl.[H]Cl
InChI key
KFFCDWFEJMZQKK-UHFFFAOYSA-N
Biochem/physiol Actions
S3226 is also known as {3-[2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methyl-phenyl]-N-isopropylidene-2-methyl-acrylamide dihydro-chloride}. S3226 is used to explore the physiological and pathophysiological functions of sodium-hydrogen exchanger 3 (NHE3) in animal models. It is a bismethacryloyl guanidine derivative.
A potent and selective NHE3 (NHE-3) inhibitor for studying NHE3 in cultures and in animals in vivo.
S3226 is a potent and selective NHE3 (NHE-3) inhibitor (IC50 = 20 nM/human NHE3, 3.6 μM/human NHE1, 80 μM/rabbit NHE2) for studying NHE3 physiological as well as pathophysiological roles in kidney and gastrointestinal disorders in vitro and in animal models in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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