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Merck
CN

SML2032

Win6mer trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

Ac-ARTEVY-NH2 trifluouroaceate salt

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About This Item

Empirical Formula (Hill Notation):
C34H54N10O11 · xC2HF3O2
CAS Number:
2222444-20-2
Molecular Weight:
778.85 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI

1S/C34H54N10O11/c1-16(2)26(32(54)42-24(28(35)50)15-20-8-10-21(47)11-9-20)43-31(53)23(12-13-25(48)49)41-33(55)27(18(4)45)44-30(52)22(7-6-14-38-34(36)37)40-29(51)17(3)39-19(5)46/h8-11,16-18,22-24,26-27,45,47H,6-7,12-15H2,1-5H3,(H2,35,50)(H,39,46)(H,40,51)(H

InChI key

DYNVFAUYAHJESK-NGPBCSSISA-N

SMILES string

C[C@H](NC(C)=O)C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=C(C=C1)O)=O)C(C)C)=O)CCC(O)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O

assay

≥98% (HPLC)

form

film (Clear)

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

Win6mer is a potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes that does not inhibit MLL2-4 or SETd1B complexes. Win6mer potently binds to WDR5 in a 310-helical conformation. It does not inhibit isolated SET domain activity.
potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000029468
0000022821

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Nilda L Alicea-Velázquez et al.
The Journal of biological chemistry, 291(43), 22357-22372 (2016-08-27)
MLL1 belongs to the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, composed of MLL1-4 and SETd1A/B. MLL1 translocations are present in acute leukemias, and mutations in several family members are associated with cancer and developmental disorders. MLL1 associates

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