SML2032
Win6mer trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
Ac-ARTEVY-NH2 trifluouroaceate salt
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About This Item
Empirical Formula (Hill Notation):
C34H54N10O11 · xC2HF3O2
CAS Number:
Molecular Weight:
778.85 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
film (Clear)
assay
≥98% (HPLC)
form
film (Clear)
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
SMILES string
C[C@H](NC(C)=O)C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=C(C=C1)O)=O)C(C)C)=O)CCC(O)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O
InChI
1S/C34H54N10O11/c1-16(2)26(32(54)42-24(28(35)50)15-20-8-10-21(47)11-9-20)43-31(53)23(12-13-25(48)49)41-33(55)27(18(4)45)44-30(52)22(7-6-14-38-34(36)37)40-29(51)17(3)39-19(5)46/h8-11,16-18,22-24,26-27,45,47H,6-7,12-15H2,1-5H3,(H2,35,50)(H,39,46)(H,40,51)(H
InChI key
DYNVFAUYAHJESK-NGPBCSSISA-N
Biochem/physiol Actions
Win6mer is a potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes that does not inhibit MLL2-4 or SETd1B complexes. Win6mer potently binds to WDR5 in a 310-helical conformation. It does not inhibit isolated SET domain activity.
potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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