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SML2054

SEA0400

Name: SEA0400
Brand: SIGMA

≥98% (HPLC), Na+−Ca++ exchanger (NCX) inhibitor, powder

Synonym(s):

SEA0400, 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine, SEA 0400

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₉F₂NO₃

CAS Number:

223104-29-8

Molecular Weight:

371.38

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD07772188

Assay:

≥98% (HPLC)

Form:

powder

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Product Name

SEA0400, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

shipped in

ambient

storage temp.

−20°C

SMILES string

CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(F)=C3)C=C2)C(N)=C1

InChI

1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3

InChI key

YSUBLPUJDOWYDP-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Potent and selective inhibitor of Na+−Ca++ exchanger (NCX)

SEA0400 is a potent and selective inhibitor of Na⁺/Ca²⁺exchanger (NCX). SEA0400 potently inhibits Na⁺/Ca²⁺ exchanger activity in rat astrocytes, microglia, cultured neurons, and rat cardiomyocytes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000495248

0000472940

0000469946

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Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation.

Torsten Christ et al.

European journal of pharmacology, 788, 286-293 (2016-07-05)

The Na(+)/Ca(2+) exchanger (NCX) plays a major role in myocardial Ca(2+) homoeostasis, but is also considered to contribute to the electrical instability and contractile dysfunction in chronic atrial fibrillation (AF). Here we have investigated the effects of the selective NCX

SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.

T Matsuda et al.

The Journal of pharmacology and experimental therapeutics, 298(1), 249-256 (2001-06-16)

The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) on the Na+-Ca2+ exchanger (NCX) was investigated and compared against that of 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943). In addition, the effects of SEA0400 on reperfusion injury in vitro and in vivo were examined. SEA0400

Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes.

Kanna Yamashita et al.

Naunyn-Schmiedeberg's archives of pharmacology, 389(11), 1205-1214 (2016-08-03)

Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and selective Na+/Ca2+ exchange (NCX) inhibitor by using various cells transfected with NCX using the 45Ca2+ fluorescent technique. However, the electrophysiological study of YM-244769 on NCX had not been

Global Trade Item Number

SKU	GTIN
SML2054-5MG	04061832568607
SML2054-25MG	04061832568591

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