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Merck
CN

SML2055

ZD0947

≥98% (HPLC)

Synonym(s):

3-[(4 S)5-Oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl] benzonitrile, 3-[(4S)-1,4,5,6,7,8-Hexahydro-5-oxo-2-(trifluoromethyl)-4-quinolinyl]-benzonitrile

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About This Item

Empirical Formula (Hill Notation):
C17H13F3N2O
CAS Number:
172649-40-0
Molecular Weight:
318.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00944017

Key Documents

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InChI

1S/C17H13F3N2O/c18-17(19,20)15-8-12(11-4-1-3-10(7-11)9-21)16-13(22-15)5-2-6-14(16)23/h1,3-4,7-8,12,22H,2,5-6H2/t12-/m0/s1

SMILES string

O=C1C2=C(NC(C(F)(F)F)=C[C@H]2C3=CC(C#N)=CC=C3)CCC1

InChI key

RUVMMEREJMHLOS-LBPRGKRZSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -625 to -575°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

potent ATP-sensitive K+ channels (KATP channels) opener
ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2) but is a partial antagonist of pancreatic-type KATP channels (i.e. SUR1/Kir6.2) and cardiac-type KATP channels (i.e. SUR2A/Kir6.2). ZD0947 potently inhibits carbacho-induced contraction in the strips of human detrusor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000029410
0000029411
0000024071

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Aly M Abdel-Karim et al.
The Journal of urology, 168(2), 837-842 (2002-07-20)
The use of K+ channel openers is emerging as an attractive possibility for treating bladder overactivity. We tested the efficacy of the 2 adenosine triphosphate dependent K channel openers ZD6169 and ZD0947 on detrusor hyperreflexia after spinal cord injury in
Keisuke Mori et al.
European journal of pharmacology, 791, 773-779 (2016-10-30)
The effects of ZD0947, a novel ATP-sensitive K
M Aishima et al.
British journal of pharmacology, 149(5), 542-550 (2006-10-04)
ATP-sensitive K+ channels (K(ATP) channels) play important roles in regulating the resting membrane potential of detrusor smooth muscle. Actions of ZD0947, a novel KATP channel opener, on both carbachol (CCh)-induced detrusor contractions and membrane currents in human urinary bladder myocytes

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