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SML2064

LBQ657

Name: LBQ657
Brand: SIGMA

≥97% (HPLC), neprilysin inhibitor, powder

Synonym(s):

(2R,4S)-5-(Biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid, Desethyl sacubitril, Sacubitrilat

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₅NO₅

CAS Number:

149709-44-4

Molecular Weight:

383.44

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD00921225

Assay:

≥97% (HPLC)

Form:

powder

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Properties

Product Name

LBQ657, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D -35 to -27°, c = 1 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O

InChI

1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1

InChI key

DOBNVUFHFMVMDB-BEFAXECRSA-N

Description

Biochem/physiol Actions

Inhibitor of neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377)

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H336,H372

pcodes

P260 - P264 - P271 - P304 + P340 + P312 - P314 - P403 + P233

Hazard Classifications

STOT RE 1 - STOT SE 3

target_organs

Bone,Kidney, Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c