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SML2077

Aliskiren hemifumarate

Name: Aliskiren hemifumarate
Brand: SIGMA

≥95% (HPLC), Renin inhibitor, powder

Synonym(s):

(2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide hemifumarate, CGP-60536, CGP60536B, Rasilez, SPP-100

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₅₃N₃O₆ · 0.5 C₄H₄O₄

CAS Number:

173334-58-2

Molecular Weight:

609.79

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD27756642

Assay:

≥95% (HPLC)

Form:

powder

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Properties

Product Name

Aliskiren hemifumarate, ≥95% (HPLC)

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CC(C)[C@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(NCC(C)(C)C(N)=O)=O)CC1=CC=C(OC)C(OCCCOC)=C1.OC(/C=C/C(O)=O)=O

InChI

1S/2C30H53N3O6.C4H4O4/c2*1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h2*10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*22-,23-,24-,25-;/m00./s1

InChI key

KLRSDBSKUSSCGU-KRQUFFFQSA-N

Description

Biochem/physiol Actions

Aliskiren hemifumarate (ALS) has been used to treat hypertension, alone or with other antihypertensive medications. It is suitable for oral administration. ALS regulates baseline systolic and diastolic blood pressure by blocking the catalytic activity of renin system at its rate-limiting step.

Aliskiren is a potent nonpeptide direct renin inhibitor with an IC50 value of 0.6 nM. It has antihypertensive activity, decreasing plasma renin activity and inhibiting the conversion of angiotensinogen to Angiotensin I by binding to the S3 sub-pocket of renin.

Direct renin inhibitor; anti-hypertensive

Storage Class

11 - Combustible Solids

wgk

WGK 3

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