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Merck
CN

SML2090

NAMI-A

≥98% ruthenium (Ru) basis (elemental analysis)

Synonym(s):

1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-κN3)[1,1′-(sulfinyl-κS)bis[methane]]ruthenate(1-) (1:1), ImH[trans-RuCl4(DMSO)Im], Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate

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About This Item

Empirical Formula (Hill Notation):
C5H10Cl4N2ORuS · C3H5N2
CAS Number:
201653-76-1
Molecular Weight:
458.18
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI key

HIAWXYSWERGOAJ-UHFFFAOYSA-K

SMILES string

CS(C)=O.Cl[Ru](Cl)(Cl)Cl.N1=CNC=C1.C2=[NH+]C=CN2

assay

≥98% ruthenium (Ru) basis (elemental analysis)

form

powder

storage condition

desiccated

color

faint red to dark brown

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

NAMI-A is a potent antimetastatic drug in vivo that is exhibits little cytotoxicity towards many cancer cell lines. Antimetastatic of NAMI-A is attributed to the formation of adducts with membrane and cytosolic proteins. Nevertheless NAMI-A induces potent and selective cytotoxic effects in several leukemia cell lines. NAMI-A exhibits low toxicity for host tissues.
NAMI-A is a ruthenium-based anticancer agent.
potent antimetastatic drug

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000029542
0000029541
0000021408

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Serena Pillozzi et al.
Dalton transactions (Cambridge, England : 2003), 43(32), 12150-12155 (2014-07-01)
We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic"
K Śpiewak et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(4), 695-703 (2015-03-21)
Imidazolium trans-tetrachloridodimethylsulfoxideimidazolruthenate(III), NAMI-A, a novel antimetastatic ruthenium complex was investigated towards affinity to transferrin (Tf), whether Tf-Ru adducts might be formed after its intravenous injection. Studies were focused on the holotransferrin due to its preferential binding to transferrin receptor. Here
Metal-DNA coordination complexes
Pizarro AM, et al.
3D printing and additive manufacturing (2013)
Alberta Bergamo et al.
Journal of inorganic biochemistry, 168, 90-97 (2017-01-09)
Solid tumours are constituted of tumour cells, healthy cells recruited from the host tissues and soluble factors released by both these cell types. The present investigation examines the capacity of co-cultures between the HCEC colon epithelial cells and the HCT-116

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