SML2090
NAMI-A
≥98% ruthenium (Ru) basis (elemental analysis)
别名:
1H-咪唑 (OC-6-11)-四氯（1H-咪唑-κN3）[1,1′-（亚磺酰基-κS）双 [甲烷]] 钌酸盐 (1-) (1:1), 反式咪唑二甲基亚砜-四氯化碳, 肌肉萎缩症 [反式-RuCl4 (DMSO) Im]
方案
≥98% ruthenium (Ru) basis (elemental analysis)
表单
powder
储存条件
desiccated
颜色
faint red to dark brown
溶解性
H2O: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
CS(C)=O.Cl[Ru](Cl)(Cl)Cl.N1=CNC=C1.C2=[NH+]C=CN2
InChI key
HIAWXYSWERGOAJ-UHFFFAOYSA-K
生化/生理作用
NAMI-A 是一种体内强效抗转移药物，对许多癌细胞株几乎无细胞毒性。NAMI-A 的抗变性归因于与膜和胞浆蛋白形成加合物。然而，NAMI-A 在几种白血病细胞系中诱导强效和选择性细胞毒性作用。NAMI-A 对宿主组织的毒性较低。
NAMI-A是一种钌基抗癌剂。
强效抗代谢药物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Metal-DNA coordination complexes
Pizarro AM, et al.
3D printing and additive manufacturing (2013)
Alberta Bergamo et al.
Journal of inorganic biochemistry, 168, 90-97 (2017-01-09)
Solid tumours are constituted of tumour cells, healthy cells recruited from the host tissues and soluble factors released by both these cell types. The present investigation examines the capacity of co-cultures between the HCEC colon epithelial cells and the HCT-116
K Śpiewak et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(4), 695-703 (2015-03-21)
Imidazolium trans-tetrachloridodimethylsulfoxideimidazolruthenate(III), NAMI-A, a novel antimetastatic ruthenium complex was investigated towards affinity to transferrin (Tf), whether Tf-Ru adducts might be formed after its intravenous injection. Studies were focused on the holotransferrin due to its preferential binding to transferrin receptor. Here
Serena Pillozzi et al.
Dalton transactions (Cambridge, England : 2003), 43(32), 12150-12155 (2014-07-01)
We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic"
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