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About This Item
Empirical Formula (Hill Notation):
C16H20F2O4
CAS Number:
Molecular Weight:
314.32
UNSPSC Code:
51111800
NACRES:
NA.77
Assay
≥98% (HPLC)
form
oil
color
colorless to light brown
storage temp.
2-8°C
SMILES string
O=C(CC(C)C)C1=CC=C(OC(F)F)C(OC2CCOC2)=C1
InChI key
IXURVUHDDXFYDR-UHFFFAOYSA-N
Biochem/physiol Actions
Anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor
Roflupram (FFPM) is a potent anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor that was found to suppress inflammasome activation in microglial cells by enhancing autophagy. In microglial BV-2 cells roflupram enhanced the level of microtubule-associated protein 1 light chain 3 II (LC3-II) and decreased the autophagy receptor ubiquitin-binding protein p62 (SQSTM1), enhancing autophagy, reducing the activation of inflammasome and suppressing the production of IL-1β. Roflupram (FFPM) was found to reverse learning and memory deficits in APP/PS1 transgenic mice.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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