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Merck
CN

SML2107

Tulathromycin A

≥95% (HPLC), powder, macrolide antibiotic

Synonym(s):

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one, CP-472295

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About This Item

Empirical Formula (Hill Notation):
C41H79N3O12
CAS Number:
217500-96-4
Molecular Weight:
806.08
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD09838804

Key Documents

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Product Name

Tulathromycin A, ≥95% (HPLC)

InChI key

GUARTUJKFNAVIK-QPTWMBCESA-N

SMILES string

C[C@@]([C@H](OC([C@@H]([C@H]1O[C@]2([H])O[C@@H](C)[C@@](O)(CNCCC)[C@@](C2)(OC)C)C)=O)CC)([C@@H]([C@H](NC[C@H](C)C[C@]([C@@H]([C@H]1C)O[C@]3([H])O[C@H](C)C[C@H](N(C)C)[C@H]3O)(O)C)C)O)O

InChI

1S/C41H79N3O12/c1-15-17-42-22-41(50)28(8)53-31(20-39(41,10)51-14)55-33-25(5)35(56-37-32(45)29(44(12)13)18-24(4)52-37)38(9,48)19-23(3)21-43-27(7)34(46)40(11,49)30(16-2)54-36(47)26(33)6/h23-35,37,42-43,45-46,48-50H,15-22H2,1-14H3/t23-,24-,25+,26-,27-,28+,29+,30-,31+,32-,33+,34-,35-,37+,38-,39-,40-,41+/m1/s1

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

Macrolide antibiotic that inhibits bacterial protein synthesis
Tulathromycin A is a macrolide antibiotic. It binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.
Tulathromycin is a triamilide antimicrobial, which is structurally similar to the di-basic azalide antibiotic azithromycin. It is used to treat bovine and swine bacterial respiratory diseases.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000502809
0000502811
0000502811
0000502809
0000445617

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Analytical procedure for the determination of tulathromycin in swine plasma
Gajda A, et al.
Bulletin of the Veterinary Institute in Pulawy, 57(2), 191-195 (2013)
Nigel A Evans
Veterinary therapeutics : research in applied veterinary medicine, 6(2), 83-95 (2005-08-12)
Tulathromycin is a novel triamilide antimicrobial that has been approved for use in the treatment and prevention of bovine respiratory disease and the treatment of swine respiratory disease in the European Union and the United States. The agent penetrates gram-negative
Qiaoyi Zhou et al.
Frontiers in pharmacology, 8, 392-392 (2017-07-14)
Tulathromycin, a macrolide antibiotic, is used for the treatment of respiratory disease in cattle and swine. The aim of our study was to investigate the
Nicolas Villarino et al.
Veterinary journal (London, England : 1997), 198(2), 352-357 (2013-11-26)
Tulathromycin is the first and only member of the triamilide sub-class of macrolides that is used therapeutically and has been registered in more than 30 countries across America, Europe, Oceania and Asia. The discovery of tulathromycin and its registration in
An analytical method for the analysis of tulathromycin, an equilibrating triamilide, in bovine and porcine plasma and lung
Galer D, et al.
Journal of Agricultural and Food Chemistry, 52(8), 2179-2191 (2004)
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