Skip to Content
Merck
CN

Key Documents

View All Documentation

SML2120

Nifekalant hydrochloride

≥98% (HPLC)

Synonym(s):

6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C19H27N5O5 · HCl
CAS Number:
130656-51-8
Molecular Weight:
441.91
UNSPSC Code:
12352200
MDL number:
MFCD00892243
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)=CC(N(C)C1=O)=O.Cl

InChI

1S/C19H27N5O5.ClH/c1-21-17(14-18(26)22(2)19(21)27)20-9-11-23(12-13-25)10-3-4-15-5-7-16(8-6-15)24(28)29;/h5-8,14,20,25H,3-4,9-13H2,1-2H3;1H

InChI key

YPVGGQKNWAKOPX-UHFFFAOYSA-N

Biochem/physiol Actions

Nifekalant is a pure potassium channel blocker and class III antiarrhythmic. It has been used to treat arrhythmias and ventricular tachycardia.
Potassium channel blocker, Antiarrhythmic agent, class III

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000035401
0000035402
0000028533

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Takashi Tagami et al.
Resuscitation, 109, 127-132 (2016-08-29)
We evaluated the association between nifekalant or amiodarone on hospital admission and in-hospital mortality for cardiac arrest patients with persistent ventricular fibrillation on hospital arrival. This was a retrospective cohort study using the Japanese Diagnosis Procedure Combination inpatient database. We
Makoto Suzuki et al.
Journal of arrhythmia, 32(3), 186-190 (2016-06-30)
Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise. Recurrence is common and may worsen a patient׳s clinical course despite appropriate treatment. This study aimed to examine the effectiveness of antiarrhythmic drugs for suppression of VTs. In this
Sou Otuki et al.
Journal of electrocardiology, 50(3), 277-281 (2017-02-28)
Patients with repetitive ventricular tachyarrhythmias - so-called electrical storm - frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefore, we investigated the efficacy of stepwise administration of nifekalant

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service