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SML2141

Solifenacin succinate

Name: Solifenacin succinate
Brand: SIGMA

≥98% (HPLC), muscarinic M3 receptors inhibitor, powder

Synonym(s):

(1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate succinate, YM905

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₆N₂O₂ · C₄H₆O₄

CAS Number:

242478-38-2

Molecular Weight:

480.55

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD00954234

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Product Name

Solifenacin succinate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +35 to +45°, c = 1 in H₂O

storage condition

desiccated

color

white to beige

solubility

H₂O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(CCC(O)=O)=O.O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=CC=CC=C4)C5=CC=CC=C5CC3

InChI

1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21?,22-;/m0./s1

InChI key

RXZMMZZRUPYENV-DZSUWJOWSA-N

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Bioactive Small Molecules

Biochem/physiol Actions

Solifenacin succinate (SOL) blocks the cholinergic signals to M3 receptors by inhibiting the muscarinic M3 receptors in the bladder. This action prevents the contractions of the detrusor muscles in the urinary bladder wall, leading to relaxing the bladder as well as decreasing urinary urgency and nocturia. Thus, SOL is a widely used antimuscarinic agent for treating the contraction of the overactive bladder.

pictograms

GHS08

signalword

Warning

hcodes

H361d

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000479871

0000448692

0000448690

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Muscarinic Receptor Binding in Rat Bladder Urothelium and Detrusor Muscle by Intravesical Solifenacin.

Yoshihiko Ito et al.

Biological & pharmaceutical bulletin, 39(7), 1167-1171 (2016-07-05)

Solifenacin is an antimuscarinic agent used to treat symptoms of overactive bladder. Pharmacologically significant amounts of solifenacin were excreted in the urine of humans taking a clinical dose of this drug. The aim of this study is to measure muscarinic

Stability-indicating HPTLC method for the simultaneous detection and quantification of alfuzosin hydrochloride, solifenacin succinate along with four of their official impurities

Tantawy MA, et al.

Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 157, 104905-104905 (2020)

Molecular docking of different ionophores host-guest inclusion complexes for electrochemical determination of solifenacin succinate in pure and pharmaceutical dosage form: Computer aided design

Eissa MS, et al.

Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 159, 105363-105363 (2020)

Long-Term Safety and Efficacy of Solifenacin in Children and Adolescents with Overactive Bladder.

Donald Newgreen et al.

The Journal of urology, 198(4), 928-936 (2017-05-17)

We evaluated the long-term safety and efficacy of once daily oral solifenacin suspension in children (5 to less than 12 years old) and adolescents (12 to less than 18 years old) with overactive bladder. We conducted a 40-week, open label extension

Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice.

Tomomi Oki et al.

British journal of pharmacology, 145(2), 219-227 (2005-03-09)

1 A novel muscarinic receptor antagonist, solifenacin succinate, inhibited specific binding of [N-methyl-(3)H]-scopolamine ([(3)H]-NMS) in the mouse bladder, submaxillary gland and heart in a concentration-dependent manner. This inhibitory effect was greatest in the submaxillary gland, followed by the bladder and

Global Trade Item Number

SKU	GTIN
SML2141-25MG	04061835253494
SML2141-100MG	04061835253487

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